In 1960, Simon attended Guildhall School of Music and Drama, London and began his acting career in one of Britain’s first television soap operas, Home Tonight with David Hemmings. For the next eleven years he worked extensively on radio and television and in provincial repertory theatre, including a year with Ian McKellen’s Hamlet.
After working as a continuity announcer and newsreader at Southern TV (1970), Prebble joined the newsroom at Capital Radio, the second commercial radio station in Britain, where he hosted London’s Day. He then embarked on a career as a presenter and voiceover, including thirteen years as the promo voice of Thames Television, as well as regular promo work for HTV and Anglia TV. He was also an announcer for Anglia TV. From 1984 he was the announcer for the British version of the phenomenally successful game show The Price Is Right with Leslie Crowther.
In 1990, Prebble moved to New York where he continued doing voiceover work. As well as recording numerous radio and television commercials, he also character-voiced cartoon series, such as Courage the Cowardly Dog; he hosted and presented several television documentary series, notably Target Mafia; and narrated the IMAX film Endurance about the Shackleton expedition. In 1996, he was a lead actor for a year (as villain Martin Chedwyn) on the American daily soap opera As the World Turns.
In the US, he also began narrating audio books. His work has gained him more than eighteen Earphone awards, nine nominations for the Audies (the audiobook Oscars), and in 2005, he was named Narrator of the Year by Publishers Weekly.
Apart from his acting career, in 1967 Prebble designed and produced the ‘executive toy’ called Newton’s Cradle.
In 2003, at Chiswick House London, he married Swedish graphic artist, Marie-Janine Hellstrom. In 2007, along with his wife, he became a US citizen.